MPX – City of Toronto

Toronto Public Health continues to follow federal and provincial guidance on the administration of Imvamune vaccines to protect at-risk populations against the MPX virus.

Based on Ontario Ministry of Health guidelines, two vaccine doses, given at least 28 days apart, are available to eligible groups.

Eligible Groups for Pre-Exposure Vaccination:

a. Two-Spirit-, non-binary, transgender, cisgender, intersex, or gender-queer individuals who self-identify or have sexual partners who self-identify as belonging to the gay, bisexual, pansexual and other men who have sex with men ( gbMSM) community AND at least one of the following:

  • Had a confirmed sexually transmitted infection (STI) within the last year;
  • Have or are planning to have two or more sexual partners or are in a relationship where at least one of the partners may have other sexual partners;
  • Have attended venues for sexual contact (eg bathhouses, sex clubs) recently or may be planning to, or who work/volunteer in these settings;
  • Have had anonymous sex (eg using hookup apps) or may be planning to; and/or
  • Are a sexual contact of an individual who engages in sex work.

b. Individuals who self-identify as engaging in sex work or are planning to, regardless of self-identified sex or gender.

c. Research laboratory employees working directly with replicating orthopoxviruses. This completed form must be provided.

Household and/or sexual contacts of people who are eligible for Pre-Exposure Vaccination listed above in parts (a) or (b) above AND who are moderately or severely immunocompromised (have a weak immune system) or are pregnant may be at risk for severe illness from an MPX infection. These individuals may be considered for Pre-Exposure Vaccination, and should contact a healthcare provider or Toronto Public Health for more information.

Eligibility for Post-Exposure Vaccination:

  • Toronto Public Health will assess the risk of exposure of a person to see if the vaccine is recommended.
  • People who have a known exposure/close contact with someone with MPX, or an exposure in a setting where MPX is spreading, should contact Toronto Public Health to find out if the vaccine is recommended to them.
  • When the vaccine is used as Post-Exposure Vaccination, it should be given within four days, but can be given up to 14 days after the last exposure.
  • Individuals who have had one dose as post-exposure vaccination can receive a second dose at least 28 days later.
    • People who are under the age of 18 should consult a healthcare provider before getting their 2n.d

Contact a healthcare provider or Toronto Public Health to find out if you are eligible for vaccination. The vaccine is free and available to all eligible people. No ID or OHIP required. Appointments are needed for City-run Immunization Clinics.

Wait to get vaccinated if you have any COVID-19 symptoms and/or you are required to self-isolate.

If you think you have MPX, isolate right away and contact a health care provider. Do not visit any MPX vaccination clinics.

The vaccine is not used as a treatment if you already have MPX. At this time, people who have or have had MPX are not eligible for the vaccine because they have immunity from the infection.

Getting the vaccine at the same time as another vaccine:

Right now, we don’t have information about getting Imvamune at the same time as other vaccines. It is recommended:

  • Not to delay getting Imvamune if you were exposed to MPX or are at high risk of exposure, even if you have recently gotten another vaccine, as the benefits are bigger than the risks.
  • After getting the Imvamune vaccine, to wait at least 2 weeks before getting another non-live vaccine (eg COVID-19, flu or meningococcal) and 4 weeks before getting another live vaccine (eg Shingles or MMR).
  • To speak with a healthcare provider if you are getting Imvamune less than 4 weeks before or after another live vaccine, as this may make the second vaccine less effective.

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